What is Cyspera Cysteamine Cream?
Cyspera was the original and first cysteamine cream. It contained 5% Cysteamine cream, which can lighten skin and treat hyperpigmentation disorders such as age spots, melasma, and postinflammatory hyperpigmentation.
This product was discontinued in 2022.
It was replaced by an improved version called Senté Cysteamine HSA Pigment & Tone Corrector containing 5% Cysteamine Cream, niacin amide and HSA in a 50ml tube.
How does Cyspera work?
As the name implies, the cream contains cysteamine, a metabolite of L-cysteine and a natural cellular component. L-cysteamine inhibits the production of melanin in the skin in several different ways which is why it is so effective.
A randomised, double-blind, placebo-controlled clinical trial confirmed the efficacy of cysteamine cream in treating epidermal melasma.
A reduction in pigmentation is usually seen after 6 weeks of consistent use. To achieve optimal results, it takes 8 to 12 weeks of regular use.
Contraindications to use:
Cysteamine cream should not be used by anyone with a personal or family history of the depigmenting disorder, vitiligo.
Do no use if you are pregnant or breast-feeding.
Can I use Cyspera in the summer?
You can use this treatment any time of year regardless of the intensity of sunlight, it is not a photosensitiser.
I have a dark skin tone can I still use it?
Yes it is suitable for all skin types and skin tones.
How to use Cyspera Cysteamine Cream
- Intensive phase: Once per day for up to 16 weeks.
- Maintenance phase: Twice-weekly, once per day, indefinitely.
- Use a high SPF sunblock to prevent activating the pigmentation.
For best results, you need to make sure you are consistent and apply it daily for the full 15 minutes.
What are the side effects and risks?
Local side effects at the site of application may include:
- Temporary heating up or burning sensation and redness that clears within 30 minutes
- More persistent irritation and dryness, which you can treat with an emollient.
A burning sensation and mild redness might occur immediately after application, but it will usually disappear after 30 minutes. This is a normal reaction and may happen during the first few days of application.
No significant side effects, other than light to mild irritation are reported in only a few cases.
In case of sustained redness, irritation or dry-skin, suspend Cysteamine application and carefully hydrate the area with your basic hydration cream. You can then gradually resume Cysteamine application once your skin has recovered — once again, not washing it off your face until it has been on the skin for 15 minutes.
Undesirable side effects are rare if:
- You leave the cream on for longer than 15 minutes of exposure.
- You do not wash your face less than 1 hour before application.
How do I avoid cysteamine cream side effects?
You can minimise side-effects by:
- Avoid washing your face just before applying.
(always wait for at least 1hr before applying) - Avoid prolonged application time use for 15 minutes only.
- Avoiding concomitant use with other topical products.
Cheshire Lasers’ prices for Cyspera Cysteamine cream
The original Cyspera Cream is no longer available you can find the prices of the available alternatives here:
Senté Cysteamine HSA Pigment & Tone Corrector 50ml
Research About Cysteamine Cream
View an article about the original cysteamine cream with some before and after case studies here.
View an article on the treatment of melasma with 5% Cysteamone cream here.
Find out more from the manufacturers’ website here.
Find out more about other pigmentation treatments at Cheshire Lasers here.
If you are interested in purchasing one of our available Cysteamine creams and would like to discuss which treatment is suitable for you, please complete the consultation form here. We will then contact you to book a consultation.
Alternatively, after completing the form, you can book a Cyspera Telephone consultation online here.
